The word TRETHERA in bold, modern font with horizontal orange bars incorporated into the letters E and H on a light background.The word TRETHERA in bold, modern font with horizontal orange bars incorporated into the letters E and H on a light background.White text TRETHERA on a light gray background, with orange horizontal bars inside the letters E and H. The design is modern and minimalistic.
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publication

Deoxycytidine kinase inhibition: Rewiring tumor nucleotide metabolism for therapeutic gain

Targeting Deoxycytidine Kinase Improves Symptoms in Mouse Models of Multiple Sclerosis

18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis

Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

Novel Positron Emission Tomography Probes Specific for Deoxycytidine Kinase

Requirement for deoxycytidine kinase in T and B lymphocyte development

Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2′-deoxycytidine analog

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White text TRETHERA on a light gray background, with orange horizontal bars inside the letters E and H. The design is modern and minimalistic.

Advancing first-in-class therapies for cancer, autoimmune disease, and ALS.

TRE-515 is an investigational drug and has not yet been approved by the FDA or any other regulatory authority. Its efficacy and safety have not been established.

© 2026 Trethera. All Rights Reserved. Trethera and other trademarks, service marks, and designs are the registered or unregistered trademarks of Trethera in the United States and other countries.

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White text TRETHERA on a light gray background, with orange horizontal bars inside the letters E and H. The design is modern and minimalistic.

Advancing first-in-class therapies for cancer and autoimmune disease.

© 2026 Trethera. All Rights Reserved.
Trethera and other trademarks, service marks, and designs are the registered or unregistered trademarks of Trethera in the United States and other countries. TRE-515 has not been FDA approved and is currently in clinical trials.

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