Trethera Corporation and KYAN Therapeutics announce collaboration to develop artificial intelligence-driven optimization of solid cancer combination therapy

Los Angeles//Singapore, October 25, 2018 /PRNewswire/ — 

Trethera Corporation (Trethera),a biopharmaceutical company committed to developing novel drugs targeting cellular nucleotide metabolism for the treatment of cancer,and KYAN Therapeutics, an artificial intelligence-based drug development firm, announced an agreement to collaborate on preclinical studies evaluating up to four different tumor types beginning this year leveraging their unique expertise to develop best-in-class combination therapies addressing unmet needs in solid tumors.

 

Under the agreement both companies will evaluatethe solid tumor responses to various novel combination therapies and dosing seen with Trethera’s compound TRE-515.  “This venture  helps Trethera to intelligently and efficiently explore the utility of our IND approved drug TRE-515 across a wide range of tumors, doses, and drug combinations” said Kenneth A. Schultz, M.D., Trethera’s Executive Chairman. “Our team is excited about developing the first therapeutic to target the salvage pathway of nucleotide synthesis, a metabolic pathway that may contribute to the progression of a variety of tumors.”

 

Founded by highly regarded UCLA faculty, Trethera focuses on pathways controlling cancer nucleotide metabolism.  TRE-515, a first-in-class inhibitor of deoxycytidine kinase (dCK), is an orally administered small molecule that has demonstrated activity in preclinical models treating a variety of tumors, both in monotherapy and when in combination with certain FDA approved drugs.

 

KYAN was initiated by a team of visionary leaders from NUS and UCLA that has successfully taken its proprietary portfolio of AI platforms through clinical validation. By uniquely demonstrating that globally optimized efficacy and safety can be achieved at each stage of drug development, from in vitrothrough preclinical and clinical validation, KYAN’s technology systematically identifies AI-driven novel drug combinations that are realized independently from conventional approaches. KYAN’s deterministic approach has led to scientific success within multiple indications tackled to date, in globally optimizing drug combinations for both composition and dosage. As such, KYAN collaborations may accelerate a biopharma company’s pathway towards first-in-man studies.

 

“KYAN is thrilled to be embarking alongside Trethera on this exciting collaboration ,” said Dean Ho, Ph.D., KYAN Co-Founder. ” Trethera’s research team has deep experience within DNA synthesis pathways and oncology therapeutic discoveries.  Combining TRE-515 with KYAN’s powerful AI optimization platforms may lead to best-in-class drug combinations that improve solid cancer treatments,” added Ho.

 

 

About TRE-515

TRE-515 is a first-in-class preclinical drug that inhibits deoxycytidine kinase (dCK), the rate-limiting enzyme in the deoxyribonucleoside salvage pathway, one of two biosynthetic pathways that generate the DNA precursors, the other being the de novopathway.  Certain cancer cells may appear preferentially dependent on the salvage pathway for nucleotides to support tumor growth. Trethera has developed TRE-515 for use as monotherapy or in combination with de novo pathway inhibitors, to precisely target a metabolic vulnerability of these cancer cells. This approach holds the potential to improve treatment efficacy and minimize the development of drug resistance.

 

About Trethera Corporation

Trethera is a privately-held biopharmaceutical company dedicated to developing novel treatments for cancers with high unmet needs. For more information, visit trethera.com.

 

About KYAN Therapeutics, Inc.

KYAN Therapeutics is a clinical-stage artificial intelligence company leveraging its proprietary technology platforms to transform the way patients are treated and therapies are developed. KYAN is able to revolutionize the drug development and dosage optimization processes and has multiple pipeline combination therapies in development for oncology and infectious diseases. KYAN de-risks and  dramatically accelerates the drug development process, identifying novel combination therapies with unprecedented efficacy and safety. KYAN’s clinically-validated platforms are uniquely disease mechanism and indication agnostic.

 

 

Press Contacts:

 

Trethera Corporation

Martin Eglitis, PhD

Meglitis@trethera.com

 

KYAN Therapeutics, Inc.

Shane Low

shane@kyantherapeutics.com

 

Note on Forward-Looking Statements

 

All statements other than statements of historical facts included in this press release that address activities, events or developments that Trethera or KYAN  expect, believe or anticipate will or may occur in the future are forward-looking statements. Although Trethera and KYAN believe that Trethera and KYAN have a reasonable basis for the forward-looking statements contained herein, Trethera and KYAN caution that such statements are based on current expectations about future events and are subject to risks, uncertainties and factors relating to medical research, all of which are difficult to predict and many of which are beyond their control, that may cause actual results to differ materially from those expressed or implied by the forward-looking statements in this press release. These potential risks and uncertainties include, without limitation, the extent to which the joint research to be conducted by Trethera and KYAN pursuant to the Development Collaboration Agreement will result in the development of any novel cancer therapies; and whether Trethera would obtain the necessary regulatory approvals to commence human trials or commercialize TRE-515 or any novel therapies resulting from such research. You are cautioned not to place undue reliance on the forward-looking statements in this press release, which speak only as of the date hereof. Trethera and KYAN do not undertake any obligation to update, amend or clarify these forward-looking statements whether as a result of new information, future events or otherwise, except as may be required under applicable securities law.

FDA Clearance of Investigational New Drug Application for TRE-515

Los Angeles, CA / February 5, 2018 – Trethera Corporation, a biopharmaceutical company committed to developing novel drugs targeting cellular nucleotide metabolism for the treatment of cancer, today announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for TRE-515, a novel, first-in-class inhibitor of deoxycytidine kinase for the treatment of patients with myelodysplastic syndromes (MDS). Under this IND, Trethera plans to initiate a Phase 1 study designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of TRE-515 as well as validate several biomarkers in relapsed and/or refractory MDS patients who have no available alternative therapy.

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Sachs Associates 10 Annual European Life Sciences CEO Forum & Exhibition, 2017

Santa Monica, CA, 26 January 2017 – Trethera, a biotechnology company focused on the discovery and development of innovative small molecules for the treatment of hematological and solid tumors will be attending Sachs Associates 10th Annual European Life Sciences CEO Forum & Exhibition being held on 6th-7th March, 2017 at the Hilton Zurich Airport Hotel, Switzerland.

For more information on Trethera’s presentations or for media enquiries, please contact trethera@instinctif.com.

UCLA Spinout Trethera Trials Novel DNA Metabolism Combination

25 January 2017
SCRIP

Emerging Company Profile: University spinout, Trethera – which recently signed a licensing deal to develop Nanotherapeutics Inc.’s ribonucleotide reductase inhibitor Triapine – believes it is the first company to target cancer nucleotide metabolism through a combination approach.

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Trethera Corporation and Nanotherapeutics Sign Exclusive Worldwide Agreement for Rights to Triapine® in Hematological Malignancies

Santa Monica, CA and Alachua, FL, January 5, 2017 – Trethera Corporation and Nanotherapeutics, Inc. today announced the signing of an exclusive worldwide agreement whereby Nanotherapeutics has granted Trethera an exclusive license for the global development, manufacturing and marketing of Triapine® (3-AP) and all formulations, for the treatment of hematological malignancies. Triapine® is a clinical-stage, small molecule inhibitor of ribonucleotide reductase (RNR), a key enzyme in the de novo pathway of nucleotide biosynthesis.

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9th Annual Biotech Showcase 2017

Santa Monica, CA, 4 January 2017 – Trethera, a biotechnology company focused on the discovery and development of innovative small molecules for the treatment of hematological and solid tumors will be attending Biotech Showcase 2017, San Francisco, USA, 9th-11th January 2017. The Company’s targeted metabolic pathway therapy approach involves using a rationally-designed combination of two or three drugs from the very start of cancer treatment.

For more information on Trethera’s presentations or for media enquiries, please contact trethera@instinctif.com.

Trethera Corporation to present at BIO Investor Forum

Beverly Hills, CA, 6 October 2016 – Trethera, a biotechnology company focused on the discovery and development of innovative small molecules for the treatment of hematological and solid tumors will be presenting at the BIO Investor Forum, San Francisco, USA, 18-19 October 2016.

Johanna Holldack, Trethera’s CEO, will be giving a Company Presentation on Tuesday, 18 October 2016 at 15:00 in the Yorkshire presentation room.

For more information on Trethera’s presentations or for media enquiries, please contact trethera@instinctif.com.

Trethera Corporation to present at BioPharm America

Beverly Hills, CA, 6 September 2016 – Trethera, a biotechnology company focused on the discovery and development of innovative small molecules for the treatment of hematological and solid tumors will be giving a Company Presentation at BioPharm America, Boston, USA, 13-15 September 2016.

For more information on Trethera’s presentations or for media enquiries, please contact trethera@instinctif.com.

Trethera Appoints Lynne Rollins as new Chief Financial Officer

Beverly Hills, CA, 21 July 2016 – Trethera, a biotechnology company focused on the discovery and development of innovative small molecules for the treatment of hematological and solid tumors today announced the appointment of Lynne Rollins as its new Chief Financial Officer (CFO). The appointment is effective immediately.

Lynne brings over 35 years’ of experience in the healthcare industry across finance, strategic planning and business development. Following senior positions at Baxter Healthcare Corporation, Lynne has advised over 30 startup medical device and biopharmaceutical companies including HighLife Medical, Syndax Pharmaceuticals and Calixa Therapeutics. Lynne has a B.S. in Finance from California State University and a MBA from Pepperdine University.

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Trethera Corporation strengthens team with two new hires

Beverly Hills, CA, 20 June 2016 – Trethera, a biotechnology company focused on the discovery and development of innovative small molecules for the treatment of hematological and solid tumors announces the appointments of Dr. Neil Bajpayee and Shailaja Srinagesh to the positions of Associate Director of Scientific Affairs and Drug Development Project Manager respectively.

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